Background : Ministry of Healthy of Republic of Indonesia in 2011 reported almost 6 million people per yearare smokers, which are 5 million people are active smokers and ex-active smokers, 600.000 people is pasive smokers. Diseases that caused died bcause cigarretes are cancer, heart disease, lungs, and stroke. Motivation is the important things to quit smoking. There are two factors that affect motivation to quit smoking, they are intrinsic and extrinsic. Pursposed : The purpose of this research is to know what factors that motivating the students of Mechanical Engineering year 2015 in Muhammadiyah Yogyakarta University. Method : This research is a quantitative. Non experimental by using Cross Sectional method. The research is done in August 2016 with 54 correspondences. Result : Analysis result of Chi Square test showed that there is a significance relation between self control and motivation to cessation smoked with value p= 0,020. Whereas, another factors are not influencing. Conclusion : There is a significance relation between self control and motivation to cessation smoked of students in Mechanical Engineering year 2015 in Muhammadiyah Yogyakarta University.