Background: Prediabetes occurs when blood sugar levels are higher than usual, one of the causes of an increase in blood sugar is cigarettes. Nowadays, it is well known for conventional cigarettes, many active cigarettes have been moved, namely electric cigarettes. The increase in the use of electric cigarettes is not in line with the research produced by e-cigarettes. Electric cigarettes have various content in them such as nicotine. As is known, the influence of nicotine on insulin is a decrease in insulin secretion, a negative effect on insulin work due to activation of the hormone catecholamine, changes in pancreatic β cells and the development of insulin resistance Objective: To determine whether there is a relationship between Electric Cigarette and blood glucose. Method: Analytical descriptive research design, the research used in this study was cross sectional. The variable accepted or dependent on this research is an increase in blood sugar. The independent or independent variable in this study is electric cigarette users. Results: This study involved 66 respondents consisting of 3 groups namely daily smokers, occasional smokers, and controls. Average daily fasting blood glucose 86.59, occasionally 81.82, controls 77.68. The Chi-Square results showed a significance of 0.72 (p> 0.05), explaining that e-cigarettes were not related to changes in fasting blood sugar. The average daily body mass index is 24.61, occasionally 23.65, controls 22.99. The Chi-Square results show a significance of 0.27 (P> 0.05) so that this result describes e-cigarettes Not related to the body mass index of the respondents. There were significant differences using the Mann Whitney analysis test namely political differences in the daily-occasional group of 0.01 (P <0.05), daily control sig 0.00 (P <0.05) and daily weight-group control control sig 0.034. (P <0.05) Conclusion: There is no significant relationship between the use of e-cigarettes and blood glucose