Since 1995, efforts to control tuberculosis (TB) with the DOTS strategy have been applied in many countries. But until now it is still one of the public health problems in the world. The most efficient effort to prevent further spread of tuberculosis (TB) germs is to treat tuberculosis (TB). In order for the tuberculosis (TB) treatment to be adequate, one of them must be monitored directly by the Companion to Take Medication until completion of treatment. The purpose of this study was to determine the type of factor and the role of companion in taking medication for the success of tuberculosis therapy. Prospective Cohort research method. The study was conducted for 6 months with a total of 57 tuberculosis patients. Primary data collection was done by interviewing using a validated questionnaire. Secondary data collection was done to obtain therapeutic data, clinical, laboratory and radiological results. The results showed that the type of companion taking medication did not have a significant relationship to the success of the therapy, the companion took medicine that had a good role at risk of 6 times to be able to experience therapeutic success and statistically significant (p = 0.011).