Abstract. For bone regeneration, one of the important key factors is the ability of the scaffold to be able to be degraded gradually at the implant side and the ability to provide a microenvironment for cells. No information available yet regarding our new synthetic coral scaffold. The purpose of this study was to observe the degradation profile and the human fibroblast gingiva proliferation on the synthetic coral scaffolds prepared from gelatin and calcium carbonate (CaCO3) in a various concentration of weight % wherein gelatin only (G) was used as a control. Scaffolds were incubated in non-phenol red DMEM for 1, 3, 6, 24, 48, and 72 h, then the supernatant was analyzed by spectrophotometer in 280 nm wavelength. After 72 hours, the degradation rate of the scaffold was accelerated using 1N HCl. The proliferation of human fibroblast gingiva was observed at 24, 48 and 72 hours after seeding 2.104 cells/ well. A plate of 96 well and DMEM were used in this study. The degradation percentage of the scaffolds within 24 hours was considered small, ranging between 4.23 - 5.15%. Meanwhile, the degradation between 24 to 72 hours incubation was confirmed at 38.35, 62.16, 52.86, 47.86, 48.42, and 53.17% for G, 7/3, 6/4, 5/5, 4/6 and 3/7 respectively. In the accelerated condition, the fastest degradation was found in G. Fibroblast proliferation increased following the incubation time except in control group and 3:7, but no significantly different between the various concentration. The fastest degradation rate was found in the scaffold without CaCO3 addition, confirming that CaCO3 in certain concentration prolonged the half-life of the scaffold. The proliferation of fibroblast increased for all incubation time.