The purpose of this research is to find out the influence of information system quality, user accounting knowledge and user expertise on the quality of accounting information with perceive ease of use as an intervening variable. Accounting information can be used by company management to make the decision, but there are still many problems related to information systems and the users of the information system used in a particular company. Accounting knowledge and user expertise are other factors that influence the quality of the produced accounting information. The research method is quantitative research with primary data. The processed questionnaires are 94 from 22 car and motorcycle dealers in Cirebon and surrounding area with purposive sampling method. The data analysis method is using multiple regression analysis. The results show perceived ease of use are positively and significantly influenced by user accounting knowledge and user expertise. Perceive ease of use is influenced positively but not significantly by the information system's quality. The quality of accounting information is influenced positively and significantly by the information system's quality, accounting knowledge and perceived ease of use but is not influenced positively and significantly by user expertise.