This study aims to analyze the factors that affect the human development index in Lampung province's districts/cities. This study uses secondary data from 2010- 2017 and the analysis tool used is the data panel method with the approach of Fixed Effect Model. Based on the results of panel data regression, it was found that the variable government expenditure on health had a positive and significant effect on the human development index in Lampung province district/city. the economy has a positive and significant effect on the human development index in Lampung province district/city, the variable number of poor people has a negative and significant effect on the human development index in Lampung province's distric/ city.