Speaking is considered as one of the main language skills besides listening, reading, and writing. By speaking, it shows someone’s knowledge measurement. Mechanical Engineering Department students at one of Private University in Yogyakarta, as EFL students, had some challenges in speaking in English. This research used case study to know the challenges faced by Mechanical Engineering Department students at one of Private University in Yogyakarta in English classroom and to know the strategies that the students used to overcome the challenges in English classroom. Multiple data collection such as interview to two students and an English teacher; also students’ speaking grade are used to know the problems. As a result, there are four findings related to the students’ challenges such as lack of vocabularies, nervousness, unsupportive environment and lack of grammar knowledge. Furthermore, there are five findings related to the strategies such as using google translate, codeswitching, seeing the audience as the statues, making personal approach to the English teacher and encouraging self