MICE stands for meeting, incentive, conference and exhibition. The MICE industry is growing quite well in Indonesia. However, today many do not yet know the positive impact of the continuation of the MICE event, especially for Indonesia's economic diplomacy. The Special Region of Yogyakarta is believed to be one of the areas used as the location for holding MICE events. The role of the MICE industry in strengthening Indonesia's economic diplomacy especially in the case of the Special Region of Yogyakarta in 2013 - 2018. This research was conducted with qualitative methods, data obtained from data were valid and were secondary data obtained from print media in the form of books, journals, magazines and newspapers . The implementation of MICE holds a significant contribution in the promotion of tourism in an area and even a country, which of course will affect the state of the economy, especially the creative economy of a country.