Abstract: In regional autonomy era, regional government obligated plan and control condition macroeconomics based on the condition of objective. Entire sectors of the economy is expected to develop and encourage other economic sectors. Development planners should maintain the leadingsectors so that the economy can be developed area. In addition, it is important to approach the non leading sector so that it becomes sub system in developing a leading sector. This research uses the Location Quotient analysis, analysis of the Shift Share, and a SWOT analysis to find out the leading subsector of agricultural sector. The result showed that the economy Karimun having six sub-sectors in agriculture. The sub-sectors were sub sectors of the food crops, orchards, vegetables, fruits, aquaculture, and fisheries.