Self-care for clients of hypertension can be improved in various ways including self-care education interventions in families. The demand for hypertension clients needs to be considered in improving care. The habits of clients in taking medication using traditional medicines include factors in changing the health behavior of hypertensive clients. Objective: To analyze the effect of self-care education on the family on hypertensive client self-care and decrease in blood pressure. Method: The design of this study was the Quasi Experiment type of The Non Equivalent Control Group Design. The sampling technique used Purposive Sampling so that it obtained 155 samples divided into 2 groups, namely the intervention group (n = 78) and controls (n = 77). Interventions in self-care education to the family include a hypertensive diet, physical activity, stress management, medication adherence, and Liquid Spray Relaxation therapy. Results: Self-care education in the family which included hypertension diet, physical activity, stress management, and medication adherence. Assessment of systolic blood pressure 160.44 mmHg and diastolic 98.06 mmHg when measuring 1 month after the intervention with p value <0.05. But the results of the measurement 3 months after the intervention were obtained for each self-care content with p value> 0.05. The value of systolic blood pressure is 165.08 mmHg and diastolic is 100.50 mmHg with p value> 0.05. Conclusions: Interventions in family self-care education can improve self-care and reduce hypertension client blood pressure when taken 1 month after intervention. When measuring 3 months after the intervention, the hypertension client's self-care decreased and blood pressure increased.