Communication is a major component in cancer care, however communication of nurses-cancer patients and families is still recognized as an ongoing challenge and issue for both nurses and patients or families. The purpose of this study is to explore nurses, cancer patients, and family perspectives on communication in cancer care. Method: This study used a qualitative method with an interpretative phenomenological approach. Sixteen participants (4 nurses, 7 cancer patients, and 5 family members) were selected through purposive sampling and conducted semi-structured interview about communication ini cancer care. Data of all interviews were transcribed and analyzed using the Colaizzi method. Results: The study found 6 main themes namely building a compassionate relationship, maintaining hope, family involvement, availability of information and direction, discussion about spiritual, and communication management in cancer care. Conclusion: Communication in cancer care aims to maintain hope and be family involvement by building a compassionate relationship, promoting spiritual discussion and providing information about cancer and its treatment.