Background: Team Based Learning (TBL) learning method as one of the learning methods that is currently widely used in developed countries. TBL can improve student learning in group collaboration, students are very actively involved in the process of learning activities to solve problems while developing professional competencies. The purpose of this study was to study the application of the TBL method to cognitive (Dementia, Incontinence Urine, Remathoid Arthritis), Self-Directed Learning Readiness (SDLR) and teamwork. Method: This type of quantitative research using quasiexsperiment method uses the design of Non-equivalent Control Group Design. Respondents of this study were 6th semester Bachelor Nursing students with 48 students, 24 intervention groups and 24 control groups. Results: This study showed that after intervention, cognitive (Dementia, Urine Incontinence, Remathoid Arthritis), SDLR and teamwork between the TBL intervention group and conventional control groups had increased, cognitive with  = 0,0001, SDLR  = 0,011 and teamwork  = 0.040. Conclusion: TBL and conventional have significant differences in cognitive ( <0.05), SDLR ( <0.05) and teamwork ( <0.05).