Background: Intradialytic exercise has been shown potential benefits on cardiovascular, dialysis adequacy, physical function, and health-related quality of life. Objective: To determine effectiveness of intradialytic exercise on dialysis adequacy and quality of life in patients with chronic kidney failure undergoing haemodialysis therapy. Methods: Experimental study using Pre-Post Test Design with Control Group, sample 48 respondents divided 24 intervention groups and 24 control groups. Range of motion exercise is done 2 times a week with a duration 15 minutes in the first two hours of haemodialysis therapy. Dialysis adequacy is measured by calculating URR, Kt/V and blood pressure. Whereas quality of life measured by KDQOL-SF 3.6. Results: Intradialytic exercise increases dialysis adequacy in terms URR P-value = 0.027 and Kt/V P-value = 0.017 and decreases systolic blood pressure P-value = 0.001. Intradialytic exercise improves quality of life in the Symptom / Problem List assessment P-value = 0,000. Effect of Kidney Disease P-value = 0.032. SF-12 Physical Health Composite P-value = 0,000. Conclusion: There were significant differences in changes between groups after the implementation of intradialytic exercise on blood pressure and physical assessment of quality of life. But not on dialysis adequacy in URR, Kt/V and mental assessment of quality of life.