Background: Nurses are the largest human resources that have an important role in healthcare services in hospitals. The challenges facing the hospital are how to realize the maximum performance of nurses. Many cases of nurses ' performance is not maximally for examples not served directly, complaints are not directly responded, providing services are not maximal, as well as writing nursing care becomes less complete. Good or poor performance of nurses is influenced by many factors both from inner self and outside factors. The factor of the inner self that is the impetus of performance among them is the organizational commitment and job satisfaction. Outside factors that are closely related to performance are leadership. Objective: To find out the influence of leadership on the work performance of nurses in RSUD KRT Setjonegoro Wonosobo. Knowing the influence of organizational commitment on the work performance of nurses in RSUD KRT Setjonegoro Wonosobo. Knowing the effect of job satisfaction on the work performance of nurses in RSUD KRT Setjonegoro Wonosobo. Method: This study is quantitative research with a cross sectional approach. The study population was nurses in the RSUD KRT Setjonegoro Wonosobo. The sampling technique in this study was purposive sampling with a total sample of 139 people. Data was collected using a questionnaire. Data analysis used multiple regression analysis. Results: Leadership has a significant effect on the work performance of nurses (p = 0.000). Organizational commitment has a significant effect on the work performance of nurses (p = 0.000). Job satisfaction has a significant effect on the work performance of nurses (p = 0.020). Leadership, organizational commitment and job satisfaction have a significant effect on the work performance of nurses in RSUD KRT Setjonegoro Wonosobo (p = 0,000). Conclusion: Leadership, organizational commitment and job satisfaction have influence in work performance of nurses in KRT Setjonegoro Hospital, Wonosobo.