The topic of this research was strategic management in educational institutions. This research‟s aim empirically examined the direct and indirect effects of strategic leadership on competitive advantage and the indirect effect mediated by unique resources. This study used Alternative Structural Equation Model namely Partial Least Square. The samples comprised of 79 from 114 course chairman that had been surveyed and returned the filled questionnaire (69 percents). The result showed the significant direct and indirect effects of strategic leadership on competitive advantage, and unique resources as intervening variable. So, to create competitive advantage, the courses had to strengthen the strategic leadership and developed unique resource. The finding of this study supported Resource Based Review, had contribution to the strategic management literature, and gave importance information to both practitioners and policy makers on the subject matter