Background : Medical waste is part of the cause of infection in hospitals, improper management of medical waste will increase the risk of Healthcare Associated Infections (HAIs) for the officers, patients, families of patients and non-medical officers in the hospital environment. The purpose of this study is to evaluate the management of medical waste and to find out the factors that influence the management of medical waste by nurses in the emergency room of PKU Muhammadiyah Hospital Bantul. Method : The type of the research is descriptive qualitative with in-depth interviewing techniques on 4 implementation nurses in the emergency room, head of the room, infection prevention and control committee (PPI) and head of the sanitation department. Results : The results of the research with the theme of supporting facilities (sub-themes of SPO availability, waste management facilities, PPI socialization), theme of the implementation process (sub-themes of waste sorting, types of waste), impact themes and constraints (sub-themes of impacts, constraints). Conclusion : The waste management process has been carried out by nurses in the emergency room, but the management process has not been carried out maximally due to the constraints of the emergency situation, officers' self-awareness and availability of facilities as needed, causing the impact of sharp object stab wounds on several nurses as well as increasing the amount of medical waste produced.