Background: The public always expects that clinical services, both government and private, can provide good and satisfying services for every user who uses them, the friendliness of the clinic, as well as the responsiveness, ability, and sincerity of clinic officers. Satisfaction experienced by patients is very closely related to the quality of services provided by the health service. The behavior of nurses and doctors in clinics is one of the most important aspects of realizing the quality of service that satisfies patients who use health services. Subjects and Methods: The applied research is quantitative research with cross sectional approach. The research subjects were patients who visited the PKU Muhammadiyah Cangkring Primary Clinic. In this study, a sample of 120 people was taken. The collected data was analyzed by SEM method with AMOS program. Results and discussion: In the first hypothesis (H1) Quality of service affects patient satisfaction. In the second hypothesis (H2) Quality of service affects patient loyalty. In the third hypothesis (H3) Patient satisfaction affects loyalty. In the fourth hypothesis (H4) patient satisfaction shows no mediation or influence between service quality and patient loyalty. Conclusion:To fulfill adequate services to attract patient loyalty, the services provided are by procedures or soups as well as meeting all the needs that include human resources, facilities, and facilities to provide maximum service.