Background: Several health professions and different educational backgrounds become a challenge for human resource management in RS. Islam Klaten. Doctors, nurses, and staff have their rights to get an appropriate salary based on the remuneration system. Employee knowledge based on remuneration regulations of RS. Islam Klaten represents their perceptions. Specifically, the researchers investigated the influence of employee perception and satisfaction on the remuneration system and its impact on employee performance. Subjects and Method: This study was quantitative research. The subject of this research was all of the employers in RS. Islam Klaten. This research used a simple random sampling method. A total of 100 employers participated in this study. The data was analyzed by using Partial least square regression to understand the influence and relationship between variables and each indicator. Results: The first hypothesis test results; employee perception influences employee satisfaction in the remuneration system in RS. Islam Klaten, with statistical value 31,781 > t table 1,985. The second hypothesis test results; employee perception of remuneration system influences the performance of hospital employees, with statistical value 2.011 > t table 1.985. The third hypothesis test results; employee satisfaction of remuneration influences employee performance at the hospital, with a statistical t value of 9,095 > t table of 1,985. Conclusion: (1) Employee perceptioninfluences employee satisfaction of the remuneration system in RS. Islam Klaten. (2) Employee perceptionof remuneration in RS. Islam Klaten influences employee performance. (3) Employee satisfaction of remuneration in RS. Islam Klaten influences employee performance.