Background: Dental caries is the sixth highest health problem in Indonesia. This has huge impact on disturbance in the quality of life, therefore we need to reduce caries by identified the risk of caries. School-age children is a group that has high caries risk especially children with orthopedically handicapped. Due to orthopedically handicapped children has a dependence in the process of cleaning their teeth and mouth. Objective: To know caries risk assessment in orthopedically handicapped children aged 6-12 years in SLB Negeri 1 Bantul Yogyakarta. Method: Descriptive observational with total sampling technique. The population of this study were all orthopedically handicapped children aged 6-12 years in SLB Negeri 1 Bantul Yogyakarta and 19 students were chosen by inclusion and exclusion criteria. Caries risk is measured by the Caries Assessment Tool (CAT) of the American Academy of Paediatric Dentistry (AAPD). Results: The results were obtained from 19 students data showed that 18 students had high risk of caries and 1 student with low risk of caries. Conclusion: Orthopedically handicapped children aged 6-12 years old in SLB Negeri 1 Bantul Yogyakarta have high risk of caries.