Background: Smoking seems to have become common among the people nowadays. Smoking behavior in Indonesia tends to increase from year to year. There are a lot of cases of death that occur in active smokers and passive smokers. The adverse effects of smoking do not appear immediately after the use of cigarettes, but will be seen in a few months or even several years. These adverse effects are including nicotine dependence and anxiety disorders that will be felt as part of the withdrawalsymptoms. Objective: This research aimsto find out whether there is a relationship between the relationship of the level of nicotine dependency and the level of anxiety in adolescent. Research Methods: This type of research is non-experimental with quantitative methods and cross sectional approaches. The sample in this research were44 people. The level of Nicotine Dependency’s instrument in this research used Fagerstrom Test for Nicotine Dependence (FTND) and instrument of anxiety level in this research usingTaylor Manifest Anxiety Scale (TMAS). Results: Based on the results of the correlation analysis between the level of nicotine dependency and the level of anxiety who used the Spearman Rho non parametric correlation test obtained a significant value of 0,000 (p> 0.05). The value of r = 0,979 which shows the direction of positive correlation with the strength of the relationship is very strong which means there is relationship between the level of nicotine dependency and the level of anxiety in adolescent. Conclusion: There is a relationship between the level of nicotine dependency and the level of anxiety in adolescent.