Abstract Background: Tuberculosis is still becoming one of the major health problems in Indonesia. The preliminary study in one lung center hospital had shown that 70% stopped taking medicine due to reducing symptom. The preliminary study had identified that the patient's lack of knowledge, including the understanding impact of incomplete treatment. Therefore, it is important to increase the knowledge, motivation and taking medicine compliance of patients with TB. Materials and Methods: The research method used quasi-experimental with pretest-posttest without control group design.. Sampling technique used accidental sampling — thirty respondents of outpatients. The health education was held using the focus group discussion (FGD) method. The discussions were initiated by sharing the experience of TB patients related to their symptoms, obstacles, how to solve problems while undergoing the treatment. Following this, the patients were given health education. Data analyzed used paired sample t-test. Results: The patient's knowledge and motivation increased, the knowledge score average (from 9,30 into 10,67) and the motivation score (from 20,73 into 22,80). Based on the statistical test, it can be concluded that there is a significant difference between knowledge and motivation score before and after health education. The patient's medication adherence is also good. This study shows how important health education which focuses more on small group discussion is, so the patient can mutually share their experience and communicate their symptom as well as obtain health education intensively. Conclusion: It has been shown that health education using focus group discussion method increased knowledge, motivation and medication adherence of respondents. Keyword: focus group discussion, health education, knowledge, motivation, tuberculosis