One of goal in the Sustainable Development Goals (SDGs) is good health and well-being for all at all age. In order to achieve the goal, research in communicable, non-communicable disease and mental health particularly in developing countries become a priority. The term life- limiting illness is used to describe illnesses where it is expected that death will be a direct consequence of the specified illness. Such illnesses may include, but are not limited to: cancer, heart disease, chronic obstructive pulmonary disease, dementia, heart failure, neurodegenerative disease, chronic liver disease and renal disease. The number of people with life-limiting illness (LLI) increase globally and lead to the increase need of palliative care. The World Health Organisation has defined palliative care as ‘an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial and spiritual’ (1). The life-limiting illness affect on physical, psychological, and spiritual that can lead to impaired human existential. Human existential is influenced by hope and suffering. The study aimed to explore hope and suffering in the palliative care context in Indonesia. The specific goal of the study include: (1)To conduct a systematic review on hope and suffering in the context of palliative care; (2) To explore hope and suffering from the perspectives of patients; (3)To explore hope and suffering from the perspectives of family caregivers, and (4) To explore hope and suffering from the perspectives of nurses.