More than one billion people are estimated to live with various types of disabilities. There are around 15% of the world population, namely 110 million (2.2%) and 190 million (3.8%) people aged 15 years and over have difficulties in performing their functions. Problems that concern persons with disabilities are among them, overweight. Overweight is currently a significant health problem in advanced societies, its prevalence is increasing worldwide, and it is a high-risk factor for non- communicable diseases. Objective: The general aim in this study was to determine the relationship of diet, physical activity and parenting with the incidence of overweight in adolescents with disabilities. This type of research is observational analytic, with a case-control design. The sampling technique used in non- probability sampling was using purposive sampling technique. The sample used was 104 consisting of 52 case groups and 52 control groups. Results: The results of the study showed that the majority of the research subjects were early adolescents (70.2%), female sex (54.8%); the most types of disabilities were mental disabilities. The results of the analysis using the chi-square test showed that there was a significant relationship between diet and physical activity with the incidence of overweight in adolescents with disabilities with a value of p <0.05. The odds ratio of the diet to overweight is 12,267 and p< 0.05. There is a relationship between diet and physical activity with the prevalence of overweight in adolescents with disabilities in Special schools for people with disabilities in West Sulawesi Province where dietary patterns tend to be excessive and physical activity tends to be mild.