As social beings, communication is an essential issue to do in each of their activities. One of the most significant communications in human life is health communication. The purpose of health communication is as a way of delivering information or messages regarding health to the community. This study employed a qualitative case study method with primary and secondary data. Primary data were obtained through in-depth interviews, while secondary data were taken from document reviews. The results of the research revealed that the Special Region of Yogyakarta (DIY) carried out health communication in an effort to support advocacy for the Non-Smoking Area (KTR) through three ways: advocacy run by socializing KTR policies, social support performed through cooperation with all elements of society, and community empowerment implemented through health education regarding the dangers of smoking to health for all aspects of society in the area.