Background: The number of cesarean sections is increasing regardless of the negative impact on women. One of the negative effects of cesarean section is postoperative pain. The pain can be managed through good communication and collaboration between health workers. Patient-Centered Care (PCC) is a treatment approach that accommodates the wants and needs of patients while minimizing the occurrence of care mismatches. PCC is fundamentally an ongoing inter-professional collaboration between doctors, nurses, nutrition, pharmacy, rehabilitation, and others. Method: This study uses the Quasi Experiment method with non equivalent control group design. The research respondents consisted of 44 people (22 respondents in the intervention group and 22 respondents in the control group) who were obtained using the Systematic random sampling method. Measurement of the level of pain performed using the Visual Analogue Scale (VAS). Results: Independent Sample T-Test showed that there were differences in the level of pain in post-cesarean section patients in the intervention group and the control group. Conclusion: Implementation of patient-centered care (PCC) can reduce the level of pain in post-cesarean section patients.