The hospital is an institution that serves individual health as a whole. Therefore the hospital must be able to manage its resources, in order to provide quality services. The purpose of this study was to the effect of the leadership to work motivation and the impact on nurse performance. This study used a mixed method. Subjects were nurses at Morotai Island Regency Hospital. A sample of 60 respondents were taken by population sampling method. Data collection was carried out by questionnaire and interview. The Quantitative analysis technique was used path analysis. The qualitative approach is carried out with a qualitative descriptive analysis technique. The results showed that 1) there was a positive influence on the leadership of the head nurse on the work motivation of nurses in Morotai Island Hospital; 2) there was no influence of the leadership of the head nurse on the performance of nurses at Pulau Morotai District Hospital; 3) there is a positive influence of work motivation on the performance of nurses at Morotai Island District Hospital. In addition, work motivation is proven to be able to mediate the relationship between the head nurse's leadership and the nurse's performance