Gamping and Depok are high endemic areas of DHF which have different trend. Gamping shows stable high while Depok shows a downward trend in 2008-2013. Some factors may affect the incidence such as agent, vector, host and environment. This study aims to determine the influence of host’s factors to dengue incidence. This is an observational analytic study with case control design. Data obtained through questionnaires distributed to respondents. There were 136 respondents each 68 respondents for control and case group. Level of knowledge, behavior and socio-economic status was measured by calculating scores. Socio-economic level was in terms of level of education, type of job and the amount of income per month. The relationships between variables were analyzed by chi-squares. The analysis showed that knowledge related to DHF with moderate strength at Gamping (p = 0,000; r = 0.453), but not associated with DHF in Depok (p = 0.420). Behavior closely associated with DHF in Gamping (p = 0.000; r = 0.643) and weakly in Depok (p = 0.002; r = 0.396). There is no relationship of socio-economic parameters in both of Gamping and Depok. Education level (Gamping p = 0.194; Depok p = 0.801), type of job (Gamping p = 0.568; Depok p = 0.422) and income per month (Gamping p = 0.570; Depok p = 0.883). It was concluded that in high endemic area with stable trend, DHF associated with knowledge and behavior, whereas in high endemic areas with a downward trend, it happened weakly related to behavior and not related with knowledge. There was no relation between DHF and socio-economic factor.