Anemia is a major nutritional problem that occurs throughout the world. the number of women aged 15-49 who suffer from anemia in six countries was 409-595 million people, the highest anemia prevalence in Indonesia is found in the group of female adolescent aged 15-19 years by 38.5%[1]. The incidence of anemia in Central Java in 2013 reached 57.1%, while in the Puskesmas (Community Health Center)Temanggung area it was still a public health problem because the prevalence reached 4.21% (Puskesmas Temanggung Data, 2018). The study aims to determine the effectiveness of Fe tablets on hemoglobin level increase in female adolescents at SMK Swadaya Temanggung. The study was conducted at SMK Swadaya Temanggung with a quasi-experimental design research type. The population of this research was female adolescents with a sample of 46 students taken by purposive sampling method. The statistical test used the Independent T-Test. The results of the study conducted on 46 female students showed that 45 female students had Hb levels> 11gr / dl and 1 female student had Hb levels <11 gr / dl. The results of the Independent T-Test showed that the value was 0.00 <0.05 indicating that Ha is accepted Ho is rejected or the administration of Fe tablets was effective against Hb levels increase in which there was a statistically significant difference between the intervention group and the control group. The school is suggested to involve all parties from the school and the health department to increase promotive efforts to overcome the problem of anemia in adolescents.