Combination wall bladder thickening on ultrasound and lekosit esterase decades often used as an adjunctive diagnostic in some cystitis cases. Purpose of this research was to determine how sensitivity and specificity of combination wall bladder thickening on ultrasound and lekosit esterase in sufferers with clinical cystitis. Method of this research is diagnostic test to determine the sensitivity and specificity of combination wall bladder thickening on ultrasound and lekosit esterase in sufferers of gold standard with cystitis clinical is bacteriological urine (urine midstream streak plate method). The results of sensitivity and specificity of this research is 80,33% and 76,92%. This value is higher than sensitivity and specificity ultrasound or lekosit esterase separately. Combination of examination is very important for skreening clinical diagnosis of cystitis. Ultrasound helps knowing the clinical causes of non infection cystitis, such as obstruction of bladder due to fibrosis, cystokele, mucous wall bladder abnormalities as there are masses, trabekulasi, prostate hypertrophy, neurogenic bladder and stone. Lekosit esterase is a parameter of the process inflammation in bladder. The Conclusion is research has a good sensitivity and specificity so that enforcement needed in diagnosis of cystitis. Keywords: ultrasound of the wall bladder thickening, lekosit esterase, sensitivity, specificity, cystitis