Background : Diabetes mellitus (DM) is one of the major problems for human health in the 21st century. The World Health Organization (WHO) predicts the more increasing number of people with diabetes in various countries including Indonesia. 1,2,3 Since the discovery of insulin, diabetes complications have shifted from acute to chronic complications namely macroangiopathy, microangiopathy and diabetic neuropathy. It contributes to the development of diabetic foot, but the pattern development is still undetermined. Objective : to determine the pattern development of diabetic foot and the role of angiopathy and neuropathy in the pathogenesis of diabetic foot Methode : A prospective cohort study Result : Has been studied 38 subjects, there are 26% men and 74% women. No significant differences in terms of age, initial GDS, the DM duration , the ulcers duration, ulcer recurrence rate and baseline score of DNS, DNE and wagner classification. The study found a significant correlation between neuropathy variable (DNS and DNE) and angiopathy variable (wagner) with p < 0,05. The higher score of DNS correlated with the higher wagner classification (p 0,42), and the higher score of DNE correlated with the higher weagner (p 0,037) Conclusion : The study found a significant correlation between neuropathy and angiopathy variable. The higher score of DNS correlated with the higher wagner classification, and the higher score of DNE correlated with the higher weagner.