Appendicitis is an inflammation of the appendix vermiformis. Management of appendicitis is with surgery (appendiktomi) that may cause postoperative pain. Analgesic tramadol is one kind of opioid analgesics, whereas ketorolac is one type of non-opioid analgesics. The study is an observational analytic study using secondary data. The subject of the study amounted to 38 people who have done appendiktomi laparoscopic group, consisted of 20 people with tramado l(tramadol group) and 18 people with ketorolac (ketorolac group). All study subjects were then calculated how long the duration of post-operation pain free. The results of this study showed that the average duration of pain-free for the tramadol group is 6.42 hours (6 hours 25 minutes), while for the ketorolac group is 5.91 hours (5 hours 54 minutes). Based on independent sample t-test analysis test, there were no significant differences in the average duration of pain-free patients in both groups (p> 0.05), so it can be concluded that tramadol and ketorolac have the same level of effectiveness in the management of pain in post appendiktomi in PKU Muhammadiyah Hospital of Yogyakarta.