One of the most important indicators that describe the success of economic development is improving the quality of human resources or commonly called the human development. This study aims to analyze the influence of gross regional domestic product, government expenditure, and the number of poor to the human development index in 33 provinces in Indonesia. This research uses secondary data which obtained from the Central Bureau of Statistic with the observation period from 2010 to 2014. Analysis tool used in this study is the pooled regression with a random effects model. The results showed the gross regional domestic product per capita and government expenditure affect positively and significantly to the human development index in Indonesia. The number of poor affect negatively and significantly to the human development index in Indonesia