Spirituality is a core part of the individual (core of individuals) that give meaning, purpose in life and connectedness. Man is a holistic creature consist of physical dimension, social, emotional, intellectual, and spiritual being one unified whole, where if one of the dimensions is interrupted it will affect other dimensions. In this concept student spirituality plays an important role in the process of adaptation of the first year students, where students begin to enter into the new environment on campus that can cause anxiety. Student spirituality will affect the mechanisms of coping committed by students to overcome the anxiety experienced by the students in the campus. Purpose: To find out correlation of spirituality level with anxiety level and coping Mechanism in the first year students of FKIK UMY. Method: Cross-sectional with Spearman correlation test for the correlation of spirituality level with the level of anxiety. Kolmogorov-Smirnov test for correlation anxiety level with Coping mechanisms. With the number of samples 224 students with proportional random sampling proportioned with the number of students in each major. Result: Result of Correlation with spearman test for the relationship of the level of spirituality with the anxiety level result in p = 0.839 (p > 0.05) and Kolmogorov-Smirnov test for correlation of spirituality level with the coping mechanism result in p = 0,636 (p > 0.05). Conclusion: There is no correlation between spirituality level with anxiety level and coping Mechanism in the first year students of FKIK UMY.