This research intended to empirically examine the whether 1.) the hospital’s image affects positively toward costumers’ loyalty, 2.) the quality of service affects positively toward customers’ loyalty, and, 3.) the customers’ satisfaction affects positively toward customers’ loyalty. The samples of the research were 100 patients who were being hospitalized in, and/or had ever been hospitalized in the RSUD PandanArangBoyolali. The data was collectedby employing questionnaire, and then was analyzed by using multiple linear regression analysis method. The samples were determined by using purposive sampling method. The data quality test was performed by using both data validity test and data reliability test. The result of the research indicated that 1.) the variable of hospital’s image affected positively toward customers’ loyalty, as seen by the coefficient value result was 0,370 and sig 0,001, 2.) the variable of quality of service affected positively toward customers’ loyalty, as seen by the coefficient value result was 0,183 and sig 0,009, and, 3.)the variable of customers’ satisfaction affected positively the customers’ loyalty, as seen by the coefficient value result was 0,177 and sig 0,005.