The unstable economic condition of a country is reflected upon the interest rate, inflation, and currency (rupiah) exchange rate and the influence of international stock index. These monetary fluctuations can influence the decrease of the share price directly and indirectly. The conditions influence the company performance. The decrease of company performance can influence the decrease of the industrial sector contribution to the national growth. The aim of the research is to analyze how far the influence of monetary fluctuations to the syariahshare price of manufacture sector in Indonesian Syariah Stock Index (ISSI). The method used in the research is regression data analysis panel. The research data are collected from yahoo finance, electronic business or cash news and Indonesian Bank (BI) report. The sampling techniques used in the research are non-probability sampling and purposive sampling. The research data are collected by using documentation technique. The result of the research shows that the independent variable can influence the dependent variablesimultaneously. Meanwhile, partially the BI interest rate and U.S. dollar exchange rate variables give negative and significant influence towards the syariah share price of the manufacture sector in ISSI.