Introduction:HAIs (Hospital-Acquired Infections) is the most commonly known complication in health care.In identifying the infection, it is important to initially analyze the risk management. One way to manage risk of HAIs is by using ICRA (Infection Control Risk Assessment). Developing risk assessment of infection control in hospital is important to prevent any unwanted infection incident. Aim: to analyze Infection Control Risk Assessment and strategies to reduce Health-Care Associated Infectionsin RS PKU Muhammadiyah Gamping Yogyakarta. Methods:This was a descriptive qualitative study with case study approach. This study used informants that were considered competent to provide information relating the infection prevention and control (IPC) program in the hospital. Data collection was conducted by in-depth interview and documents review. Results and Discussion:Identification of HAIs in RS PKU Muhammadiyah Gamping found risks such as (1) microorganisms infection transmission by direct and indirect contact; (2) infections; (3) treatment duration, prolonged of stay, disability; (4) health care professionals, patients, visitor, treatment area and hospital surroundings.Analysis and risk assessment of HAIs resulted that HAIs with the highest risk was surgical site infection.Strategies of infection reduction were stopping the infection transmission, identifying HAIs bacteria, rational use of antibiotic, optimizing HAIs surveillance, regular meeting and discussion of things related to HAIs, reporting, cooperation, evaluation, socialization and monitoring of HAIs and its prevention, and refreshing of HAIs standard operating procedures. Suggestion: The managements of RS PKU Muhammadiyah Gamping should put more attention to implementation of infection prevention and control program.