Diabetes melitus (DM) especially DM type 2 is the 4th biggest cause of death. The metabolic condition in a person with diabetes is indicated with the high level of blood glucose. This condition can cause various complication, acute, and chronic complication. A comprehensive treatment on DM is needed to prevent acute and chronic complications. According to Perkumpulan Endokrinologi Indonesia (PERKENI) in 2011, there are 4 main pillars in treating DM, they are education, medical nutrient therapy, exercise or physical activity, and pharmacology intervention. Senam ADUHAI is a head to leg exercise which includes simple and easy movements. This research is aimed at revealing the effectiveness of senam ADUHAI (Atasi Diabetes Untuk Hidup Sehat dan Ideal) on the decreasing of Total Cholesterol levels in blood at Diabetes Melitus type 2. Method: This research is a pre-experimental research involving one group pre-test and post-test design. The sample of the research included 17 people with diabetes mellitus type 2 at PERSADIA RS PKU Muhammadiyah Yogyakarta Unit 1. Comparative test Paired Sample T Test was used to analyze the data. Result: The prevalence diabetes melitus type 2 in woman was higher than men (65%;35%). Meanwhile, diabetes melitus type 2 mostly occurs in 45-64 years old rather than in ≥ 65 years old (76%;34%). The Paired Sample Test analysis result show p= 0,01 (significant) Conclusions: There is dcreasing of Total Cholesterol level in a person with diabetes melitus type 2 at Persatuan Diabetes Indonesia (PERSADIA) GROUP RS PKU Muhammadiyah Yogyakarta Unit 1 before and after senam ADUHAI. With that, senam ADUHAI can be use as therapy to prevent the complication of diabetes melitus type2.