Diabetes mellitus (DM) especially DM type 2 is the 4th biggest cause of death. The metabolic condition in a person with diabetes is indicated with the high level of blood glucose that can trigger dyslipidemia, marked by the low level of High Density Lipoprotein (HDL). This condition can cause various complication, acute and chronic complication. A comprehensive treatment on DM is needed to prevent acute and chronic complications. According to Perkumpulan Endokrinologi Indonesia (PERKENI) in 2011, there are 4 main pillars in treating DM, there are education, medical nutrient therapy, exercise or physical activity, and pharmacology intervention. Senam ADUHAI is a head to leg exercise which includes simple and easy movements. This research is aimed at revealing the effectiveness of senam ADUHAI (Atasi Diabetes Untuk Hidup Sehat dan Ideal) on the increasing of HDL levels in blood at Diabetes Mellitus type 2. Method: This research is a pre-experimental research involving one group pre-test and post-test design. The sample of the research included 17 people with diabetes mellitus type 2 at Persatuan Diabetes Indonesia (PERSADIA) group RS PKU Muhammadiyah Yogyakarta Unit 1. Comparative test Paired-sample T Test was used to analyze the data. Result: The prevalence of diabetes mellitus type 2 in women was higher than men (65%:35%). Meanwhile, diabetes mellitus type 2 mostly occurs in 45-64 years old rather than in ≥65 years old (76:24%). The Paired-sample T test analysis result show p=0,44 (not significant). Conclusion: There is no increasing of HDL level in a person with diabetes mellitus type 2 at Persatuan Diabetes Indonesia (PERSADIA) group RS PKU Muhammadiyah Yogyakarta Unit 1 before and after senam ADUHAI. According to the result, senam ADUHAI can not be use as therapy to prevent the complication of diabetes mellitus type 2.