| dc.contributor.advisor | I, INDRAYANTI | |
| dc.contributor.author | UTAMI, ADE AYUNINGSIH | |
| dc.date.accessioned | 2017-04-25T07:50:42Z | |
| dc.date.available | 2017-04-25T07:50:42Z | |
| dc.date.issued | 2016-12-28 | |
| dc.identifier.uri | http://repository.umy.ac.id/handle/123456789/10194 | |
| dc.description | Latar belakang : Pada tahun 2012 di seluruh dunia terdapat 1,7 juta kasus baru
kanker payudara. Pengetahuan tentang HER-2 dan ukuran tumor dapat
dimanfaatkan sebagai indikator terbaik untuk faktor prognostik dan terapi kanker
payudara. Fungsi dari HER-2 sangat berkaitan dalam pengaturan pertumbuhan
ukuran tumor. Ketika terjadi ekspresi yang berlebihan dari HER-2 akan
menyebabkan pertumbuhan ukuran tumor menjadi tidak terkendali. Studi ini
dilakukan untuk menentukan hubungan antara HER-2 dengan ukuran tumor pada
pasien kanker payudara.
Tujuan penelitian : Untuk mengetahui hubungan antara overekspresi HER-2
dengan ukuran tumor pada pasien kanker payudara.
Metode : Cross sectional study dilakukan terhadap 72 pasien dengan diagnosis
kanker payudara yang sudah dilakukan pemeriksaan imunohistokimia (HER-2) dan
histopatologis (ukuran tumor). Pengambilan sampel penelitian dari Januari hingga
Desember 2015. Analisa data dengan uji Chi-Square dilakukan secara bertahap
meliputi analisis univariat dan bivariat.
Hasil dan Pembahasan : Dari 72 sampel penelitian didapatkan pasien dengan
ukuran tumor ≤5 cm dan >5cm sebanyak 47 (65,3%) dan 25 (34,7%) pasien. Pada
ukuran ≤2 cm dan >2 cm sebanyak 24 (33,3%) dan 48 (66,7%) pasien, Sedangkan
pada ekspresi HER-2 positif sebanyak 26 (36,1%) pasien dan HER-2 negatif
sebanyak 46 (63,9%). Dengan menggunakan uji korelasi Chi-square didapatkan
nilai P=0,119 pada ukuran tumor ≤5 cm dan >5cm serta P=0,489 pada ukuran tumor
≤2 cm dan >2 cm untuk hubungan antara ukuran tumor dengan overekspresi HER-
2.
Kesimpulan : Tidak ada hubungan bermakna secara statistik overeskpresi HER-
2 dengan ukuran tumor yang besar pada pasien kanker payudara. | en_US |
| dc.description.abstract | Background: In 2012, worldwide there were 1.7 million new cases of breast
cancer. Knowledge of HER-2 and tumor size can be used as the best indicator of
prognostic factors and treatment of breast cancer. The function of the HER-2
strongly associated in the setting of tumor size growth. When there is
overexpression of HER-2 will lead to growth in the size of the tumor had become
unmanageable. This study was conducted to determine the comparation between
HER-2 with the size of tumors in breast cancer patients.
Aim: To determine the comparation between overexpression of HER-2 with tumor
size in patients with breast cancer.
Methods: Cross sectional study was carried out against 72 Patients with a
diagnosis of breast cancer that has been conducted immunohistochemical
examination (oncoprotein HER-2/neu) and histopathological (tumor size).
Sampling research from January to December 2015. Data were analyzed by Chi-
Square test done gradually include univariate and bivariate analysis.
Results: From 72 samples obtained from the study of patients with tumor size ≤5
cm and> 5cm by 47 (65.3%) and 25 (34.7%) patients. In size ≤2 cm and> 2 cm by
24 (33.3%) and 48 (66.7%) patients, while the expression HER-2 positive in 26
(36.1%) patients and HER-2 negative with 46 (63.9%). By using the Chi-square
test of correlation values obtained P = 0.119 for the size tumor ≤5 cm and> 5cm
and P = 0.489 for tumor size ≤2 cm and> 2 cm for the comparation between the
size of the tumor with overexpression of HER-2.
Conclusion: No comparation was statistically significant overexpression of HER-
2 with large tumor size in patients with breast cancer. | en_US |
| dc.publisher | FKIK UMY | en_US |
| dc.subject | Breast cancer, HER-2/neu, tumor size. Background: In 2012, worldwide there were 1.7 million new cases of breast cancer. Knowledge of HER-2 and tumor size can be used as the best indicator of prognostic factors and treatment of breast cancer. The function of the HER-2 strongly associated in the setting of tumor size growth. When there is overexpression of HER-2 will lead to growth in the size of the tumor had become unmanageable. This study was conducted to determine the comparation between HER-2 with the size of tumors in breast cancer patients. Aim: To determine the comparation between overexpression of HER-2 with tumor size in patients with breast cancer. Methods: Cross sectional study was carried out against 72 Patients with a diagnosis of breast cancer that has been conducted immunohistochemical examination (oncoprotein HER-2/neu) and histopathological (tumor size). Sampling research from January to December 2015. Data were analyzed by Chi- Square test done gradually include univariate and bivariate analysis. Results: From 72 samples obtained from the study of patients with tumor size ≤5 cm and> 5cm by 47 (65.3%) and 25 (34.7%) patients. In size ≤2 cm and> 2 cm by 24 (33.3%) and 48 (66.7%) patients, while the expression HER-2 positive in 26 (36.1%) patients and HER-2 negative with 46 (63.9%). By using the Chi-square test of correlation values obtained P = 0.119 for the size tumor ≤5 cm and> 5cm and P = 0.489 for tumor size ≤2 cm and> 2 cm for the comparation between the size of the tumor with overexpression of HER-2. Conclusion: No comparation was statistically significant overexpression of HER- 2 with large tumor size in patients with breast cancer. | en_US |
| dc.title | HUBUNGAN OVEREKSPRESI HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER-2) DENGAN UKURAN TUMOR PADA PASIEN KANKER PAYUDARA | en_US |
| dc.type | Thesis
SKR
FKIK
489 | en_US |
