HUBUNGAN JUMLAH LEUKOSIT DARAH PERIFER DAN SKOR KARNOFSKY PADA PASIEN KANKER PAYUDARA
Abstract
Background : The specific body immune system that is described by peripheral blood leukocytes (T lymphocytes, B lymphocytes and NK cells) has a protective role in recognizing and destroying cancer cells in the body. This protective role determines the patient's performance status, evaluates the outcomes of therapy and determines the prognosis of cancer patients. Assessment of Karnofsky score is used to assess the patient's performance status, functional state, evaluates the outcomes of therapy and determines the prognosis in all cancer patients.
Objective : to determine the relationship of the number of peripheral blood leukocytes and Karnofsky Score in breast cancer patients.
Method : This was a nonexperimental study with cross-sectional design. This study used retroprespective data that was taken from medical records and laboratory results of peripheral blood samples of breast cancer patients in June 2016 - August 2017. The relationship between the number of peripheral blood leukocytes and Karnofsky score was analyzed by Spearman's correlation test. Result : The result of this study with a total of 70 patients, 8 (11.4%) patients had leukocyte counts below the normal range, 36 (51.4%) patients had leukocyte counts in the normal range and 26 (37.1%) of patients had leukocyte counts above the normal range. The result of karnofsky score was the most patients with karnofsky score of 90% that was 29 (41,4%) patients and at least 50% with karnofsky score that was 2 (2.9%) patients. Statistical result showed that there was a significant relationship between the number of peripheral blood leukocytes and Karnofsky score in breast cancer patients (p = 0.000). Medium strength correlation value with correlation in opposite direction (r = -0,518). Conclusion : There is a correlation between increased of the number of peripheral blood leukocytes with decreased of the functional state of breast cancer patients that was assessed by Karnofsky Score with medium-strength correlations.