The study aims to know the influence of the domestic investment capital or Penanaman Modal Dalam Negeri (PDMN), the Foreign Direct Investment (FDI), and Anggaran Pengeluaran Belanja Daerah (APBD), and the labor toward the economic growth in 5 regions/cities in DIY between 2006-2012. The data that is used in this study is the secondary data, with the time series model (2006-2012) and the cross section model (5 regions in DIY). The result shows that the PDMN has positive influence and is significant; the increasing number of PDMN around 1% will make the economic growth increases 0, 10 in each region in DIY. The APBD also has positive influence and significant; the increasing number of APBD around 1% will make the economic growth increases 0, 10. The labor has negative impact and significant; the increasing number of labor around 1% will make the economic growth decreases -0,67 in each region in DIY, it shows that the marginal utility of labor will increase the marginal utility of production. The marginal utility production will keep increasing if the labor keeps adding until maximum. When the production reaches maximum the increasing number of total labor will decrease the total production (TP) that will make the production negative.