Background: Indonesian people have dental caries with DMF-T index 4,58 (high). Central Java especially in Kebumen regency has DMF-T index which is at 7,2 (very high). Caries has a negative impact on preschool children, especially in the quality of life. Objective: To know the correlation between dental caries status with quality of life (Oral Health Related Quality of Life) on preschool children in TK (Kindergarten) Pertiwi Kebumen. Method: This research is observational analytics using cross sectional design. The research subjects were 102 respondents taken using simple random sampling technique. The research subjects were students of TK Pertiwi Kebumen aged 4-6 years. The dental caries status was measured using the def-t index (WHO) while the quality of life impact was measured using ECOHIS (WHO). Data analyzed using Spearman’s correlation. Result: Based on the Spearman’s test results, the correlation strength value (r) is 0,662 and the p value is 0,000 (<0,005) so there is a significant correlation between the status of dental caries with the quality of life (Oral Health Related Quality of Life). Mean def-t value of def-t is 8,9 (very high) and worse ECOHIS status as much as 45%. Conclusion: There is a significant correlation between dental caries status with the quality of life (Oral Health Related Quality of Life) on preschool children on TK Pertiwi Kebumen where dental caries status is very high and the quality of life is worse