|dc.contributor.author||WULANDARI, TRI KURNIA||
|dc.description.abstract||Wound is the loss of integrity of the skin epithelium. The wound is an injury that is often
experienced by every human being. Wound healing process is divided in 3 phases: 1).
Hemostasis and inflammation, 2). Proliferation and 3). Maturation and remodeling.Proliferation
phase which happens at the 5th-21st day will increase after Fibroblasts wound happens. Black
cumin (Nigella Sativa) has an active substance that can increase the number of fibroblast cells
namely Saponin, Flavonoid and Thymoquinone. The effect of saponins on fibroblasts is to
synthesize fibronectin which can accelerate wound healing.
The type of this study was experimental laboratory invivo with post test only control
group design design.Type of this research was experimental of invivo laboratory with the design
of post-test only control group. This research used 36 mice which were divided being 3 treatment
groups; those were positive control (aloclair), treatment control (jintanhitam gel), and negative
control (CMC-Na). Gingiva mice were injured using a scalpel with a diameter of 5 mm. After
that, gingival tissue was taken and made preparation. Observation with 20x40 magnification
with 10x viewable field using a light microscope.
The result of this study werw tested by Kruskal-Wallis with the result that there was a
significant (p<0,05) difference to the increase of the number of fibroblast cells between 3
treatment groups based on the action. The Kruskal-Wallis test based on dy showed no significant
(p>0,05) result from each treatment group. This study showed that Nigella sativa gel can
increase the number of fibroblast cells to the wound healing process in rat gingiva.||en_US
|dc.publisher||FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS MUHAMMADIYAH YOGYAKARTA||en_US
|dc.subject||Black Cumin (Nigella Sativa)||en_US
|dc.title||PENGARUH PEMBERIAN GEL BIJI JINTAN HITAM (Nigella Sativa) PADA PROSES PENYEMBUHAN LUKA GINGIVA||en_US
|dc.title.alternative||ditinjau dari jumlah sel fibroblast||en_US