This research aims to analyze influence level of Gross Regional Domestic Product (PDRB), Electricity Infrastructure and Government Expenditure on Education Development Index in South Sumatera Province. The object of this research are datas of 11 districts and 4 cities during 2013 until 2015 that was obtained from various agencies such as BPS and sources related to this research. Analyzer used by using panel data method. Based on the analysis, it is obtained that the GRDP and Infrastructure Electricity have a significant positive effect on the Human Development Index in South Sumatera Province. On the other side, Government Expenditure which alocated to Education Development has no effect on Human Development Index in South Sumatera Province.