Background: Pre-hypertension is a category used to identify a patient who is at high risk to have hypertension. Pre-hypertension is the level of someone’s blood pressure at 130/90 or 80/89. Based on the Journal Neurology from University of California, San Diego School of Medicine that people who have blood pressure, which tends to high or pre-hypertension, have 55 percent higher risk of stroke compare to people with normal blood pressure. The use of modern hypertension medications can cause side effects, therefore traditional medicine could be an option by the community, and one of them is a banana (Musa paradisiaca ). The activities of Angiotensin Converting Enzyme Inhibitors (ACE-I) contained in bananas can lower blood pressure inside the body. Banana also contains high levels of potassium and low levels in sodium, so it is good for people with pre-hypertension. Methods: The type of this research is a method pre-experimental (one group pretest and posttest design). They were 25 people and had been meeting the exclusion criteria and inclusion criteria needed. In this study, there was only one variable, namely blood pressure response is the reactivity value obtained by calculating the difference between the pretest and posttest. Data analysis was using SPSS data processing that is paired sample t-test for normally distributed data and Wilcoxon signed rank test for abnormal distributed data. Result: Pretest-posttest systolic value by Wilcoxon signed rank test for asymp. Sig (2-tailed) p is 0.0001 (<0.05), so that H1 is accepted, which means there is a significant difference between the systolic blood pressure before and after treatment. So was the diastolic, diastolic value pretest-posttest by Wilcoxon signed rank test for asymp. Sig (2-tailed) p is 0.0001 (<0.05), so that H1 is accepted, which means there is a significant difference between the diastolic blood pressure before and after treatment. Conclusion:showed that there is a decline in systolic and diastolic blood pressure response on the subject after being treated with banana (Musa paradisiaca )