This study aims to determine the effect of fed rate, world gold price, inflation and money supply (M2) on jakarta islamic index (JII), this type of research is quantitative by using time series data from 2011 to 2016, data analysis was used multiple regression analysis, The significance level used in this research was 5%, the result of this study shows that the fed rate, gold price, inflation and money supply (M2) influence simultaneously and significantly to JII with F-probability value 0.000000, while partially fed rate had negative and insignificant effect on JII with probability value 0.0862, world gold price had positive and significant influence to JII with probability value 0.0051, inflation had positive and insignificant effect to JII with probability value 0.6020, and the last amount of money supply probability value of 0.0000 means had a positive and significant influence on JII..