The purpose of this research is to analyze the factors that affecting Gross Domestic Regional Product of West Kalimantan period 1986-2016. Dependent variable using PDRB of West Kalimantan, in the other hand the independent variable is PMDN, PMA, the productive land area and Labor Force. This research use time series data from the period 1986-2016 which is sourced from Badan Pusat Statistik of West Kalimantan. The analytical method used in this research is ordinary least square (OLS) method, with the aid of Eviews 7.0. The results of the research shows that the variable of PMA, the productive land area, and Labor Force statistically give a positive and significant effect through PDRB in West Kalimantan, besides the variable of PMDN statistically not affected to PDRB in West Kalimantan.