Background: Streptococcus mutans is a bacteria which colonize in teeth surface and causes dental caries, ciplukan plants are annual herbal plants which can be found in various tropical areas over the world. Ciplukan leaves (Physalis angulata L.) contain polyphenols, alkaloid, and flavonoid which have a good antimicrobial activities. Research objective: To find the influence of antibacterial power of ciplukan (Physalis angulata L.) extract mouthwash toward the bacteria of Streptococcus mutans. Research methodology: This research is a pure laboratory experiment which use the Streptococcus mutans bacteria duplications. The bacteria is incubated in the ciplukan (Physalis angulata L.) extract mouthwash in the concentration of 5%, 10%, 15%, 20%, and 25% for 18-24 hours in the temperature of 37 degree Celcius. As its control, the basic formula of mouthwash is used as the positive control and Chlorexidine gluconate 0.2% is used as the negative control. The testing of antibacterial power uses the liquid dilution which is continued by using the solid dilution. The statistical analysis test applies descriptive testing. Research findings: The research finding shows that ciplukan leaves (Physalis angulata L.) extract mouthwash has the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) at the same condition in the 5% concentration. Conclusion: Ciplukan leaves (Physalis angulata L.) extract mouthwash has the influence of Inhibitory concentration and Bactericidal concentration toward the bacteria of Streptococcus mutans.