Background: Chronic kidney failure is an irreversible and progressive renal damage. Hemodialysis is the most frequent method for chronic kidney failure patients which affect patients’ quality of life. Depression is the most common psychiatric disorder found in chronic kidney failure patients which can worsen the disease and cause complications. This study aims to identify the effect of Spiritual Emotional Freedom Technique (SEFT) to reduce depression level in chronic kidney failure patients undergoing hemodialysis at PKU Gamping Hospital. Method : This study use quantitative approach with quasi experimental two group pretest-post test with control group design. Samples were recruited using consecutive sampling. 20 respondents were divided into two groups: 10 respondents as the control group and 10 respondents as the intervention group. Level of depression in intervention group and control group were measured using Beck Depression Inventory II (BDI-II) questionnaire. Intervention group was given SEFT (set up, tune in, and tapping) in three times for 30 minutes before level of depresion in both groups were measured again using BDI-II. Data were analyzed by using Wilcoxon test and independent t test.. Result : The average of pretest and post test score in the control group were 23.10 and 21.3 respectively, while in the intervention group were 23.4 and 16.8 respectively. Wilcoxon test result analysis between levels of depression before and after SEFT intervention in the intervention group showed p=0.008 (p<0.05), while in the control group showed p=0.342 (p>0.05). Independent sample t test result analysis measuring depression level change between both groups showed p=0.047 (p<0.05). Conclusion : There were significant differences between levels of depression before and after SEFT intervention in the intervention group. This research benefits that SEFT can be used to reduce depression level in chronic kidney failure patients undergoing hemodialysis at PKU Gamping Hospital.