Background: Smoking has become a part of the lifestyle where smokers get a false pleasure as well as bad for the health of smokers themselves and people exposed to tobacco smoke. WHO data shows the prevalence of smokers in the world more than 1.3 billion, and a third of them are population age 15 years and over. An estimated 900 million people or about 84% live in developing countries, including Indonesia. Indonesia is 3rd most after China and India with numbers reached 146.86 million. In addition, secondhand smoke causes and makes severe conditions of various respiratory tract disorders including asthma and rhinitis, especially in children. Tobacco smoke contains irritants respiratory tract such as sulfur dioxide, nitrogen that can affect the increased activity of Th2 and IgE production, IgE increased by various mechanisms and local inflammation in the respiratory tract. So there is an increase in contact between the tissues with allergens that arise an immune. The smoke inhaled by passive smokers is more toxic and therefore irritate the airway mucosa. Although there is evidence that exposure to tobacco smoke is harmful to children’s respiratory health, the effects of tobacco smoke exposure on the regulation of immunoglobulin E (IgE)-mediated immune responses to specific allergens remain unclear. Aim: to determine the effect of secondhand smoke exposure on IgE levels in children of primary school. Methods: an observational study with cross sectional approached. Children aged 10–12 years (N = 57) were assessed using ISAAC questionnaire. Blood samples were collected for the quantitative measurement of total immunoglobulin type E with the IMMULITE 2000 systema analyzers by Prodia Laboratory. Results: The 57 children (32 girls and 25 boys) with secondhand smoke exposure included in this study and ranged in age from 10-12 year. There was no effect of tobacco smoke exposure with statistically significant IgE levels with P = 0.545. The effect of tobacco smoke exposure with a statistically significant environment is a public place with P = 0.038. Conclusion: These data suggest that children with secondhand smoke exposure showed the increasing of total IgE level, but there were no statistically significant affect between tobacco smoke exposure and gender, personal history of allergic diseases, or household passive smoke on IgE sensitization.